American actor Alexis Arquette was BOTD in 1969. Born in Los Angeles, California to a showbiz family, she was assigned male at birth. Identifying as female from early childhood, she made her screen debut in 1986 in Down and Out in Beverly Hills, and became well known in Los Angeles’ LGBTQ community for her drag performances as Eva Destruction. She became more widely known playing a trans sex worker in the harrowing 1989 film of Hubert Selby Jr’s Last Exit to Brooklyn. She had supporting roles in independent films throughout the 1990s, from the high-end (Pulp Fiction) to the mildly controversial (Threesome) to the deeply trashy (Bride of Chucky, Children of the Corn V), and had a memorable cameo as a Boy George-obsessed sidekick in the rom-com The Wedding Singer. She also played Roman emperor Caligula in TV fantasy series Xena: Warrior Princess, and appeared in an episode of the sitcom Friends opposite her sister-in-law Courtney Cox. In 2006, she underwent gender confirmation surgery, an experience recounted in the 2007 documentary Alexis Arquette: She’s My Brother, featuring interviews with her actor siblings David, Patricia and Rosanna. She died in 2016 of an HIV-related illness, aged 47.